Article
Genetic determinants of acute inflammation regulate Salmonella infection and modulate Slc11a1 gene (formerly Nramp1) effects in selected mouse lines.
Microbes and infection - 1 Oct 2006
Borrego Andrea, Peters Luciana Carla, Jensen José Ricardo, Ribeiro Orlando Garcia, Koury Cabrera Wafa Hanna, Starobinas Nancy, Seman Michel, Ibañez Olga Martinez, De Franco Marcelo
Abstract excerpt
Two lines of mice selected to produce maximal (AIRmax) or minimal (AIRmin) acute inflammatory reactions (AIR) differ in their susceptibility to infection by Salmonella enterica serotype Typhimurium (S. Typhimurium). The LD(50) for AIRmax mice is 1000 times higher than that observed for AIRmin mice, and higher frequencies of Slc11a1 alleles (known to confer either resistance (R) or high susceptibility (S) to S....
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