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Article

Genetic control of IL-1 beta production and inflammatory response by the mouse Irm1 locus.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2010

Vorraro Francisca, Galvan Antonella, Cabrera Wafa Hanna Koury, Carneiro Patricia Santos, Ribeiro Orlando Garcia, De Franco Marcelo, Starobinas Nancy, Jensen José Ricardo, Seman Michel, Dragani Tommaso A, Ibañez Olga Célia Martinez

Abstract excerpt

Genome-wide linkage analysis using single nucleotide polymorphism arrays was carried out in pedigrees of mice differing in the extent of acute inflammatory response (AIRmax or AIRmin). The AIR phenotype was determined by quantifying the number of infiltrating cells in the 24-h exudate induced by Biogel P-100 s.c. injection and by ex vivo IL-1beta production by leukocytes stimulated with LPS and ATP. We mapped the...

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Identifiers

PMID: 20610646
DOI: 10.4049/jimmunol.1000358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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