Article
Pulmonary adenoma susceptibility 1 (Pas1) locus affects inflammatory response.
Oncogene - 23 Jan 2003
Maria Durvanei Augusto, Manenti Giacomo, Galbiati Federica, Ribeiro Orlando Garcia, Cabrera Wafa Hanna Koury, Barrera Roberto Giannì, Pettinicchio Angela, De Franco Marcelo, Starobinas Nancy, Siqueira Maria, Dragani Tommaso A, Ibañez Olga Martinez
Abstract excerpt
Two outbred mouse lines, phenotypically selected for differential subcutaneous (s.c.) acute inflammatory response (AIR), were analysed for urethane-induced lung inflammatory response and susceptibility to lung tumorigenesis. AIR(min) mice, which show a low response to s.c. acute inflammation, developed a persistent subacute lung inflammatory response and a 40-fold higher lung tumor multiplicity than did AIR(max)...
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