Article
Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Feb 2014
Corneth Odilia B J, Mus Adriana M C, Asmawidjaja Patrick S, Klein Wolterink Roel G J, van Nimwegen Menno, Brem Maarten D, Hofman Yara, Hendriks Rudi W, Lubberts Erik
Abstract excerpt
OBJECTIVE: Interleukin-17A (IL-17A) signals through the IL-17 receptor (IL-17R) A/C heterodimer. IL-17RA serves as a common receptor subunit for several IL-17 cytokine family members. Lack of IL-17RA signaling may therefore have additional effects beyond those of lack of IL-17A alone. The present study was undertaken to determine the role of IL-17RA signaling in autoimmune arthritis. METHODS: Disease incidence...
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