Article
Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 2004
Ghilardi Nico, Kljavin Noelyn, Chen Qi, Lucas Sophie, Gurney Austin L, De Sauvage Frederic J
Abstract excerpt
The heterodimeric cytokine IL-23 consists of a private cytokine-like p19 subunit and a cytokine receptor-like subunit, p40, which is shared with IL-12. Previously reported IL-12p40-deficient mice have profound immune defects resulting from combined deficiency in both IL-12 and IL-23. To address the effects of specific IL-23 deficiency, we generated mice lacking p19 by gene targeting. These mice display no overt...
Topics
- Animals
- Antibody Formation
- CD4-Positive T-Lymphocytes
- Dendritic Cells
- Gene Deletion
- Hypersensitivity, Delayed
- Immunocompromised Host
- Interleukin-23
- Interleukin-23 Subunit p19
- Interleukins