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Article

The IL‐17 pathway as a major therapeutic target in autoimmune diseases

13 Dec 2010

Abstract excerpt

Th17 cells are a subset of T helper cells that have been recently found to play important functions in host defense and the pathogenesis of various human autoimmune and inflammatory diseases. Th17 cells produce IL-17A, IL-17F, IL-22, and IL-21, of which IL-17A and IL-17F mediate many of the downstream pathologic functions of these cells. IL-17A and IL-17F signal through IL-17RA and IL-17RC heterodimeric receptors...

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PMID: 21155836
DOI: 10.1111/j.1749-6632.2010.05825.x

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