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An essential role of interleukin-17 receptor signaling in the development of autoimmune glomerulonephritis

16 Jun 2014

Abstract excerpt

In recent years, proinflammatory cytokines in the nephritic kidney appear to contribute to the pathogenesis of AGN. The complex inflammatory cytokine network that drives renal pathology is poorly understood. IL-17, the signature cytokine of Th17 cells, which promotes autoimmune pathology in a variety of settings, is beginning to be identified in acute and chronic kidney diseases as well. However, the role of...

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PMID: 24935958
DOI: 10.1189/jlb.3a0414-184r

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