Immunity to infection in IL ‐17‐deficient mice and humans

Abstract excerpt

Mice with defective IL-17 immunity display a broad vulnerability to various infectious agents at diverse mucocutaneous surfaces. In humans, the study of patients with various primary immunodeficiencies, including autosomal dominant hyper-IgE syndrome caused by dominant-negative STAT3 mutations and autosomal recessive autoimmune polyendocrinopathy syndrome type 1 caused by null mutations in AIRE, has suggested...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immunodeficiency and Autoimmune Disorders
• Share to T-cell and B-cell Immunology
• Share to Whipple's Disease and Interleukins