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Article

Antibody blockade of IL-17 family cytokines in immunity to acute murine oral mucosal candidiasis.

Journal of leukocyte biology - 1 Jun 2016

Whibley Natasha, Tritto Elaine, Traggiai Elisabetta, Kolbinger Frank, Moulin Pierre, Brees Dominique, Coleman Bianca M, Mamo Anna J, Garg Abhishek V, Jaycox Jillian R, Siebenlist Ulrich, Kammüller Michael, Gaffen Sarah L

Abstract excerpt

Antibodies targeting IL-17A or its receptor, IL-17RA, are approved to treat psoriasis and are being evaluated for other autoimmune conditions. Conversely, IL-17 signaling is critical for immunity to opportunistic mucosal infections caused by the commensal fungus Candida albicans, as mice and humans lacking the IL-17R experience chronic mucosal candidiasis. IL-17A, IL-17F, and IL-17AF bind the IL-17RA-IL-17RC...

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Share to Antibodies, Blocking
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibodies, Neutralizing

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Share to Mouth Mucosa

Source

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Identifiers

PMID: 26729813
DOI: 10.1189/jlb.4A0915-428R
PMCID: PMC4952011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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