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Article

The function of interleukin 17 in the pathogenesis of rheumatoid arthritis

29 Sept 2007

Abstract excerpt

Interleukin (IL)-17 is a 30- to 35-kDa homodimeric polypeptide cytokine cloned in 1993 and originally named cytotoxic T lymphocyte-associated antigen-8 (CTLA-8). Sequencing the human genome resulted in the discovery of an additional five members of the IL-17 family that were consecutively named IL-17B to IL-17F. IL-17A is exclusively produced by a newly identified CD4+ T-helper subset that was recently named...

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PMID: 18219763
DOI: 10.1007/s00005-007-0032-8

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