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Article

Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis.

Journal of autoimmunity - 1 Feb 2018

van Hamburg Jan Piet, Tas Sander W

Abstract excerpt

T helper 17 (Th17) cells are important mediators of immune responses against extracellular bacteria and fungi, and as such play critical regulatory roles in maintaining mucosal homeostasis. Conversely, Th17 cells and their effector molecules interleukin 17A (IL-17A), IL-17F, interferon (IFN)γ, tumor necrosis factor (TNF)α, and granulocyte-macrophage colony-stimulating factor (GM-CSF) are implicated in the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29254845
DOI: 10.1016/j.jaut.2017.12.006

Genes

CCR6
CSF2
EOMES
ETS1
GATA3
IKZF3
IRAK1
PRDM1
PRKCQ
RBPJ
RUNX1
TAGAP
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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