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Article

Mice with targeted inactivation of ppap2b in endothelial and hematopoietic cells display enhanced vascular inflammation and permeability.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2014

Panchatcharam Manikandan, Salous Abdel K, Brandon Jason, Miriyala Sumitra, Wheeler Jessica, Patil Pooja, Sunkara Manjula, Morris Andrew J, Escalante-Alcalde Diana, Smyth Susan S

Abstract excerpt

OBJECTIVE: Lipid phosphate phosphatase 3 (LPP3), encoded by the PPAP2B gene, is an integral membrane enzyme that dephosphorylates, and thereby terminates, the G-protein-coupled receptor-mediated signaling actions of lysophosphatidic acid (LPA) and sphingosine-1-phosphate. LPP3 is essential for normal vascular development in mice, and a common PPAP2B polymorphism is associated with increased risk of coronary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24504738
DOI: 10.1161/ATVBAHA.113.302335
PMCID: PMC4001868

Genes

LPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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