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Article

Lipid phosphate phosphatase 3 negatively regulates smooth muscle cell phenotypic modulation to limit intimal hyperplasia.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2013

Panchatcharam Manikandan, Miriyala Sumitra, Salous Abdelghaffar, Wheeler Jessica, Dong Anping, Mueller Paul, Sunkara Manjula, Escalante-Alcalde Diana, Morris Andrew J, Smyth Susan S

Abstract excerpt

OBJECTIVE: The lipid phosphate phosphatase 3 (LPP3) degrades bioactive lysophospholipids, including lysophosphatidic acid and sphingosine-1-phosphate, and thereby terminates their signaling effects. Although emerging evidence links lysophosphatidic acid to atherosclerosis and vascular injury responses, little is known about the role of vascular LPP3. The goal of this study was to determine the role of LPP3 in the...

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Identifiers

PMID: 23104851
DOI: 10.1161/ATVBAHA.112.300527
PMCID: PMC3524385

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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