Article
Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis.
The Journal of allergy and clinical immunology - 1 Jul 2016
Hox Valerie, O'Connell Michael P, Lyons Jonathan J, Sackstein Paul, Dimaggio Thomas, Jones Nina, Nelson Celeste, Boehm Manfred, Holland Steven M, Freeman Alexandra F, Tweardy David J, Olivera Ana, Metcalfe Dean D, Milner Joshua D
Abstract excerpt
BACKGROUND: During IgE-mediated immediate hypersensitivity reactions, vascular endothelial cells permeabilize in response to mast cell mediators. We have demonstrated previously that patients and mice with signal transducer and activator of transcription 3 (STAT3) mutations (autosomal dominant hyper-IgE syndrome [AD-HIES]) are partially protected from anaphylaxis. OBJECTIVES: We sought to study the mechanism by...
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