Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

doi:10.1093/cvr/cvw217

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Article

Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.

Cardiovascular research - 1 Dec 2016

Touat-Hamici Zahia, Weidmann Henri, Blum Yuna, Proust Carole, Durand Hervé, Iannacci Francesca, Codoni Veronica, Gaignard Pauline, Thérond Patrice, Civelek Mete, Karabina Sonia A, Lusis Aldons J, Cambien François, Ninio Ewa

Abstract excerpt

AIMS: Lipid phosphate phosphatase 3; type 2 phosphatidic acid phosphatase β (LPP3; PPAP2B) is a transmembrane protein dephosphorylating and thereby terminating signalling of lipid substrates including lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). Human LPP3 possesses a cell adhesion motif that allows interaction with integrins. A polymorphism (rs17114036) in PPAP2B is associated with coronary...

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PMID: 27694435
DOI: 10.1093/cvr/cvw217
PMCID: PMC5157138

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