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Article

The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability.

The Journal of biological chemistry - 14 Dec 2012

Souza Cleiton Martins, Davidson Dominique, Rhee Inmoo, Gratton Jean-Philippe, Davis Elaine C, Veillette André

Abstract excerpt

Protein-tyrosine phosphatase (PTP)-PEST (PTPN12) is ubiquitously expressed. It is essential for normal embryonic development and embryonic viability in mice. Herein we addressed the involvement of PTP-PEST in endothelial cell functions using a combination of genetic and biochemical approaches. By generating primary endothelial cells from an inducible PTP-PEST-deficient mouse, we found that PTP-PEST is not needed...

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Source

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Identifiers

PMID: 23105101
DOI: 10.1074/jbc.M112.387456
PMCID: PMC3522311

Genes

PTPN12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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