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Article

LPCAT3 deficiency in hematopoietic cells alters cholesterol and phospholipid homeostasis and promotes atherosclerosis.

Atherosclerosis - 1 Aug 2018

Thomas Charles, Jalil Antoine, Magnani Charlène, Ishibashi Minako, Queré Ronan, Bourgeois Thibaut, Bergas Victoria, Ménégaut Louise, Patoli Danish, Le Guern Naig, Labbé Jérôme, Gautier Thomas, de Barros Jean Paul Pais, Lagrost Laurent, Masson David

Abstract excerpt

BACKGROUND AND AIMS: LPCAT3 plays a major role in phospholipid metabolism in the liver and intestine. However, the impact of LPCAT3 on hematopoietic cell and macrophage functions has yet to be described. Our aim was to understand the functions of LPCAT3 in macrophages and to investigate whether LPCAT3 deficiency in hematopoietic cells may affect atherosclerosis development. METHODS: Mice with constitutive Lpcat3...

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Share to Arachidonic Acid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ATP Binding Cassette Transporter 1

Share to ATP Binding Cassette Transporter, Subfamily G, Member 1

Share to Liver X Receptors

Share to Phospholipids

Share to Plaque, Atherosclerotic

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Source

Identifiers

PMID: 29866392
DOI: 10.1016/j.atherosclerosis.2018.05.023

Genes

LPCAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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