Article

The PNUTS-PP1 axis regulates endothelial aging and barrier function via SEMA3B suppression

2020-08-10

Abstract excerpt

<h4>ABSTRACT</h4> Age-related diseases pose great challenges to health care systems worldwide. During aging, endothelial senescence increases the risk for cardiovascular disease. Recently, it was described that Phosphatase 1 Nuclear Targeting Subunit (PNUTS) has a central role in cardiomyocyte aging and homeostasis. Here, we determined the role of PNUTS in endothelial cell aging. We confirmed that PNUTS is repres...

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Literature Corpus work: 6901f93e-78f6-5cf5-a908-8d3344997725
DOI: 10.1101/2020.08.10.243170

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