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Article

Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.

Circulation research - 31 Jul 2015

Wu Congqing, Huang Ru-Ting, Kuo Cheng-Hsiang, Kumar Sandeep, Kim Chan Woo, Lin Yen-Chen, Chen Yen-Ju, Birukova Anna, Birukov Konstantin G, Dulin Nickolai O, Civelek Mete, Lusis Aldons J, Loyer Xavier, Tedgui Alain, Dai Guohao, Jo Hanjoong, Fang Yun

Abstract excerpt

RATIONALE: PhosPhatidic Acid Phosphatase type 2B (PPAP2B), an integral membrane protein known as lipid phosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery disease (CAD) by genome-wide association studies. However, it is unclear whether genome-wide association studies-identified coronary artery disease genes, including PPAP2B, participate in mechanotransduction...

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Topics

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Share to Aorta, Thoracic
Share to Hemodynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kruppel-Like Transcription Factors

Share to Mechanotransduction, Cellular

Share to Myosin Light Chains

Share to Phosphatidate Phosphatase

Share to Regional Blood Flow

Share to Stress, Mechanical

Source

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Identifiers

PMID: 26034042
DOI: 10.1161/CIRCRESAHA.117.306457
PMCID: PMC4522239

Genes

KLF2
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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