Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.

Gastroenterology - 1 May 2014

Sanders Theodore J, McCarthy Neil E, Giles Edward M, Davidson Katherine L M, Haltalli Myriam L R, Hazell Sophie, Lindsay James O, Stagg Andrew J

Abstract excerpt

BACKGROUND & AIMS: Reduced generation of all-trans retinoic acid (RA) by CD103(+) intestinal dendritic cells (DCs) is linked to intestinal inflammation in mice. However, the role of RA in intestinal inflammation in humans is unclear. We investigated which antigen-presenting cells (APCs) produce RA in the human intestine and whether generation of RA is reduced in patients with Crohn's disease (CD). METHODS: Ileal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Dehydrogenase 1 Family
Share to Ileum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrin alpha Chains

Share to Lipopolysaccharide Receptors

Share to Receptors, Retinoic Acid

Share to Retinal Dehydrogenase

Share to Retinoic Acid Receptor alpha

Share to Tretinoin

Source

Identifiers

PMID: 24503130
DOI: 10.1053/j.gastro.2014.01.057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease.PMID 24503130Read ↗

Generation and transcriptional programming of intestinal dendritic cells: essential role of retinoic acid.Semantic proximity Read ↗

Retinoic acid regulates the development of a gut-homing precursor for intestinal dendritic cells.Semantic proximity Read ↗

The mucosal factors retinoic acid and TGF-β1 induce phenotypically and functionally distinct dendritic cell types.Semantic proximity Read ↗

Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms.Semantic proximity Read ↗

Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids.Semantic proximity Read ↗

Retinoic acid controls the homeostasis of pre-cDC-derived splenic and intestinal dendritic cells.Semantic proximity Read ↗

IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2.Semantic proximity Read ↗

Butyrate and retinoic acid imprint mucosal-like dendritic cell development synergistically from bone marrow cells.Semantic proximity Read ↗

Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid.Semantic proximity Read ↗

Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease.Semantic proximity Read ↗

Continuous retinoic acid induces the differentiation of mature regulatory monocytes but fails to induce regulatory dendritic cells.Semantic proximity Read ↗

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.