Article
Modulation of dendritic cell alternative activation and function by the vitamin A metabolite retinoic acid.
International immunology - 1 Nov 2015
Jones Lucy H, Cook Peter C, Ivens Alasdair C, Thomas Graham D, Phythian-Adams Alexander T, Allen Judith E, MacDonald Andrew S
Abstract excerpt
The archetypal Th2 cytokine IL-4 has previously been shown to alternatively activate murine macrophages and, more recently, dendritic cells (DCs) both in vitro and in vivo. IL-4 has also been shown to induce Aldh1a2 (aldehyde dehydrogenase 1a2) expression in murine macrophages recruited to the peritoneal cavity. However, the influence of IL-4 on DC Aldh1a2 induction in vivo has not yet been addressed. In this...
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