Article
Immunomodulation by Bifidobacterium infantis 35624 in the murine lamina propria requires retinoic acid-dependent and independent mechanisms.
PloS one - 1 Jan 2013
Konieczna Patrycja, Ferstl Ruth, Ziegler Mario, Frei Remo, Nehrbass Dirk, Lauener Roger P, Akdis Cezmi A, O'Mahony Liam
Abstract excerpt
Appropriate dendritic cell processing of the microbiota promotes intestinal homeostasis and protects against aberrant inflammatory responses. Mucosal CD103(+) dendritic cells are able to produce retinoic acid from retinal, however their role in vivo and how they are influenced by specific microbial species has been poorly described. Bifidobacterium infantis 35624 (B. infantis) feeding to mice resulted in...
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