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Article

IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2013

Zhu Bing, Buttrick Thomas, Bassil Ribal, Zhu Chen, Olah Marta, Wu Chuan, Xiao Sheng, Orent William, Elyaman Wassim, Khoury Samia J

Abstract excerpt

Although activated inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs) are potent T cell suppressors, nonactivated IMCs and IDCs promote T cell activation and Th1/Th17 cell differentiation. In this study, we investigated how to reduce the proinflammatory properties of IMCs and IDCs and further convert them into immune regulatory dendritic cells (DCs). We found that IL-4 and retinoic acid (RA)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23960232
DOI: 10.4049/jimmunol.1300329
PMCID: PMC3773474

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