Article
Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease.
Gastroenterology - 1 Dec 2013
Ogino Takayuki, Nishimura Junichi, Barman Soumik, Kayama Hisako, Uematsu Satoshi, Okuzaki Daisuke, Osawa Hideki, Haraguchi Naotsugu, Uemura Mamoru, Hata Taishi, Takemasa Ichiro, Mizushima Tsunekazu, Yamamoto Hirofumi, Takeda Kiyoshi, Doki Yuichiro, Mori Masaki
Abstract excerpt
BACKGROUND & AIMS: Abnormal activity of innate immune cells and T-helper (Th) 17 cells has been implicated in the pathogenesis of autoimmune and inflammatory diseases, including Crohn's disease (CD). Intestinal innate immune (myeloid) cells have been found to induce development of Th17 cells in mice, but it is not clear if this occurs in humans or in patients with CD. We investigated whether human intestinal...
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