Article
Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids.
The American journal of pathology - 1 Mar 2012
McDonald Keely G, Leach Matthew R, Brooke Kaitlin W M, Wang Caihong, Wheeler Leroy W, Hanly Elyse K, Rowley Christopher W, Levin Marc S, Wagner Michael, Li Ellen, Newberry Rodney D
Abstract excerpt
Dendritic cells (DCs) use all-trans retinoic acid (ATRA) to promote characteristic intestinal responses, including Foxp3(+) Treg conversion, lymphocyte gut homing molecule expression, and IgA production. How this ability to generate ATRA is conferred to DCs in vivo remains largely unstudied. Here, we observed that among DCs, retinaldehyde dehydrogenase (ALDH1), which catalyzes the conversion of retinal to ATRA,...
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