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Article

Structural and functional characterization of cargo-binding sites on the μ4-subunit of adaptor protein complex 4.

PloS one - 1 Jan 2014

Ross Breyan H, Lin Yimo, Corales Esteban A, Burgos Patricia V, Mardones Gonzalo A

Abstract excerpt

Adaptor protein (AP) complexes facilitate protein trafficking by playing key roles in the selection of cargo molecules to be sorted in post-Golgi compartments. Four AP complexes (AP-1 to AP-4) contain a medium-sized subunit (μ1-μ4) that recognizes YXXØ-sequences (Ø is a bulky hydrophobic residue), which are sorting signals in transmembrane proteins. A conserved, canonical region in μ subunits mediates recognition...

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Identifiers

PMID: 24498434
DOI: 10.1371/journal.pone.0088147
PMCID: PMC3912200

Genes

APP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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