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Article

Recruitment of the Mint3 adaptor is necessary for export of the amyloid precursor protein (APP) from the Golgi complex.

The Journal of biological chemistry - 4 Oct 2013

Caster Amanda H, Kahn Richard A

Abstract excerpt

The amyloid precursor protein (APP) is a ubiquitously expressed single-pass transmembrane protein that undergoes proteolytic processing by secretases to generate the pathogenic amyloid-β peptide, the major component in Alzheimer plaques. The traffic of APP through the cell determines its exposure to secretases and consequently the cleavages that generate the pathogenic or nonpathogenic peptide fragments. Despite...

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Share to Adaptor Proteins, Signal Transducing
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Golgi Apparatus

Share to Lysosomal-Associated Membrane Protein 1

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Source

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Identifiers

PMID: 23965993
DOI: 10.1074/jbc.M113.481101
PMCID: PMC3789957

Genes

APP
LAMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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