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Article

Dynamic conformational changes in munc18 prevent syntaxin binding.

PLoS computational biology - 1 Mar 2011

Bar-On Dana, Nachliel Esther, Gutman Menachem, Ashery Uri

Abstract excerpt

The Sec1/munc18 protein family is essential for vesicle fusion in eukaryotic cells via binding to SNARE proteins. Protein kinase C modulates these interactions by phosphorylating munc18a thereby reducing its affinity to one of the central SNARE members, syntaxin-1a. The established hypothesis is that the reduced affinity of the phosphorylated munc18a to syntaxin-1a is a result of local electrostatic repulsion...

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Identifiers

PMID: 21390273
DOI: 10.1371/journal.pcbi.1001097
PMCID: PMC3048386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Dynamic conformational changes in munc18 prevent syntaxin binding.PMID 21390273Read ↗

Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly.Semantic proximity Read ↗

Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3.Semantic proximity Read ↗

Syntaxin opening by the MUN domain underlies the function of Munc13 in synaptic-vesicle priming.Semantic proximity Read ↗

Tyrosine phosphorylation of Munc18-1 inhibits synaptic transmission by preventing SNARE assembly.Semantic proximity Read ↗

SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion.Semantic proximity Read ↗

Discrimination of GLUT4 vesicle trafficking from fusion using a temperature-sensitive Munc18c mutant.Semantic proximity Read ↗

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.Semantic proximity Read ↗

Syntaxin binding mechanism and disease-causing mutations in Munc18-2Semantic proximity Read ↗

Extension of Helix 12 in Munc18-1 Induces Vesicle Priming.Semantic proximity Read ↗

The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p.Semantic proximity Read ↗

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.Semantic proximity Read ↗

Rescue of Munc18-1 and -2 double knockdown reveals the essential functions of interaction between Munc18 and closed syntaxin in PC12 cells.Semantic proximity Read ↗

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