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Article

Open-closed motion of Mint2 regulates APP metabolism.

Journal of molecular cell biology - 1 Feb 2013

Xie Xingqiao, Yan Xiaojie, Wang Zheng, Zhou Hao, Diao Wentao, Zhou Weihong, Long Jiafu, Shen Yuequan

Abstract excerpt

The amyloid-β protein precursor (APP) plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Knock-out and transgenic mouse studies of the adaptor protein Mint2 have revealed that it is a major player in regulating APP metabolism physiologically through the binding of its phosphotyrosine-binding (PTB) domain to the intracellular domain of APP. However, the molecular mechanism of APP dynamically...

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Source

Identifiers

PMID: 22730553
DOI: 10.1093/jmcb/mjs033

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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