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Article

Structural basis for the dynamic conformations of AP-4 and its association with ARF1.

Nature communications - 21 Jan 2026

Wang Yanghui, Li Wei, Qiu Yunlong, Wu Si, Hong Liu, Zhao Yan, Feng Wei

Abstract excerpt

Among the distinct adaptor protein (AP) complexes, AP-4 primarily functions as a non-clathrin-coated vesicle machinery essential for intracellular membrane trafficking. ARF1 is a master regulator of AP-4 membrane recruitment, but the underlying mechanism remains elusive. Here, we present the cryo-EM structures of soluble AP-4 and the AP-4/ARF1 complex. Unexpectedly, AP-4 adopts a dynamic equilibrium between...

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Identifiers

PMID: 41565640
DOI: 10.1038/s41467-026-68679-8
PMCID: PMC12923877

Genes

ARF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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