Article

Tight control of the APP-Mint1 interaction in regulating amyloid production

2022-10-08

Abstract excerpt

Generation of amyloid-beta (Aβ) peptides through the proteolytic processing of the amyloid precursor protein (APP) is one pathogenic event in Alzheimer’s disease (AD). APP is a type I transmembrane protein and endocytosis of APP mediated by the endocytic YENPTY sequence is a key step in Aβ generation. We and others have found that Mints, a family of cytosolic adaptor proteins, directly binds to the YENPTY motif of...

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Literature Corpus work: 4ad1922a-afd2-536d-9ced-09c92d4b1ab7
DOI: 10.1101/2022.10.07.511363

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