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The Epsilon Hinge‐Ear Region Regulates Membrane Localization of the AP‐4 Complex

2 Aug 2011

Abstract excerpt

Adaptor protein (AP) complexes are key factors for the spatial and temporal regulation of intracellular trafficking events. Four complexes (AP-1, -2, -3, -4) are known, among which AP-4 is only poorly characterized. Recent work suggests a role for AP-4 in the intracellular trafficking of the β-amyloid precursor protein and molecular genetics showed that the loss of functional AP-4 is associated with congenital...

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PMID: 21810154
DOI: 10.1111/j.1600-0854.2011.01262.x

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