Article
Intraclonal heterogeneity is a critical early event in the development of myeloma and precedes the development of clinical symptoms.
Leukemia - 1 Feb 2014
Walker Brian A, Wardell Christopher P, Melchor Lorenzo, Brioli Annamaria, Johnson David C, Kaiser Martin F, Mirabella Fabio, Lopez-Corral Lucia, Humphray Sean, Murray Lisa, Ross Mark, Bentley David, Gutiérrez Norma C, Garcia-Sanz Ramón, San Miguel Jesus, Davies Faith E, Gonzalez David, Morgan Gareth J
Abstract excerpt
The mechanisms involved in the progression from monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) to malignant multiple myeloma (MM) and plasma cell leukemia (PCL) are poorly understood but believed to involve the sequential acquisition of genetic hits. We performed exome and whole-genome sequencing on a series of MGUS (n=4), high-risk (HR)SMM (n=4), MM (n=26) and PCL (n=2)...
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