Article
Genomic patterns of progression in smoldering multiple myeloma.
Nature communications - 22 Aug 2018
Bolli Niccolò, Maura Francesco, Minvielle Stephane, Gloznik Dominik, Szalat Raphael, Fullam Anthony, Martincorena Inigo, Dawson Kevin J, Samur Mehmet Kemal, Zamora Jorge, Tarpey Patrick, Davies Helen, Fulciniti Mariateresa, Shammas Masood A, Tai Yu Tzu, Magrangeas Florence, Moreau Philippe, Corradini Paolo, Anderson Kenneth, Alexandrov Ludmil, Wedge David C, Avet-Loiseau Herve, Campbell Peter, Munshi Nikhil
Abstract excerpt
We analyzed whole genomes of unique paired samples from smoldering multiple myeloma (SMM) patients progressing to multiple myeloma (MM). We report that the genomic landscape, including mutational profile and structural rearrangements at the smoldering stage is very similar to MM. Paired sample analysis shows two different patterns of progression: a "static progression model", where the subclonal architecture is...
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