Genomically Smoldering Multiple Myeloma Is Not a Distinct Entity But a Collection of Monoclonal Gammopathy of Undetermined Significance or Multiple Myeloma.

doi:10.1200/JCO-25-00289

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Article

Genomically Smoldering Multiple Myeloma Is Not a Distinct Entity But a Collection of Monoclonal Gammopathy of Undetermined Significance or Multiple Myeloma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2026

Aktas Samur Anil, Corre Jill, Talluri Srikanth, Shah Parth, Graffeuil Antoine, Rivera Joshua, Fan Yiyang, Dakiki Korucu Bahar, Szalat Raphael, Fulciniti Mariateresa, Anderson Kenneth C, Sperling Adam, Parmigiani Giovanni, Avet-Loiseau Hervé, Munshi Nikhil C, Samur Mehmet Kemal

Abstract excerpt

PURPOSE: The diagnosis of smoldering multiple myeloma (SMM) primarily relies on clinical features such as plasma cell involvement, immunoglobulin protein levels, and end-organ damage. However, as early intervention becomes a priority, the role of genomic features in differentiating risk is gaining attention. METHODS: This study analyzed next-generation sequencing data from 224 precursor condition samples with 51...

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PMID: 41380103
DOI: 10.1200/JCO-25-00289
PMCID: PMC13267264

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