Article
The SORL1 polymorphism rs985421 may confer the risk for amnestic mild cognitive impairment and Alzheimer's disease in the Han Chinese population.
Neuroscience letters - 20 Mar 2014
Jin Chunhui, Zhang Lili, Xian Yiping, Liu Xiaowei, Wu Yue, Zhang Feng, Zhu Jianzhong, Zhang Guofu, Chen Caixia, Gong Ronglan, Zhang Lingyun, Yuan Jianmin, Zhang Fuquan, Tian Lin, Wang Guoqiang, Cheng Zaohuo
Abstract excerpt
Although the pathogenetic mechanisms driving Alzheimer's disease (AD) are unclear, genetic variations may play an important role. Previous studies have identified that single nucleotide polymorphisms (SNPs) in the sortilin-related receptor, L (DLR class) A repeats containing (SORL1) gene are associated with AD or amnestic mild cognitive impairment (aMCI) patients. However, the association of SORL1 variants with...
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