Article
Chromatin immunoprecipitation indirect peaks highlight long-range interactions of insulator proteins and Pol II pausing.
Molecular cell - 20 Feb 2014
Liang Jun, Lacroix Laurent, Gamot Adrien, Cuddapah Suresh, Queille Sophie, Lhoumaud Priscillia, Lepetit Pierre, Martin Pascal G P, Vogelmann Jutta, Court Franck, Hennion Magali, Micas Gaël, Urbach Serge, Bouchez Olivier, Nöllmann Marcelo, Zhao Keji, Emberly Eldon, Cuvier Olivier
Abstract excerpt
Eukaryotic chromosomes are partitioned into topologically associating domains (TADs) that are demarcated by distinct insulator-binding proteins (IBPs) in Drosophila. Whether IBPs regulate specific long-range contacts and how this may impact gene expression remains unclear. Here we identify "indirect peaks" of multiple IBPs that represent their distant sites of interactions through long-range contacts. Indirect...
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