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Article

Genome-wide localization of exosome components to active promoters and chromatin insulators in Drosophila.

Nucleic acids research - 1 Mar 2013

Lim Su Jun, Boyle Patrick J, Chinen Madoka, Dale Ryan K, Lei Elissa P

Abstract excerpt

Chromatin insulators are functionally conserved DNA-protein complexes situated throughout the genome that organize independent transcriptional domains. Previous work implicated RNA as an important cofactor in chromatin insulator activity, although the precise mechanisms are not yet understood. Here we identify the exosome, the highly conserved major cellular 3' to 5' RNA degradation machinery, as a physical...

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Identifiers

PMID: 23358822
DOI: 10.1093/nar/gkt037
PMCID: PMC3597698

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CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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