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Article

A major epigenetic programming mechanism guided by piRNAs.

Developmental cell - 11 Mar 2013

Huang Xiao A, Yin Hang, Sweeney Sarah, Raha Debasish, Snyder Michael, Lin Haifan

Abstract excerpt

A central enigma in epigenetics is how epigenetic factors are guided to specific genomic sites for their function. Previously, we reported that a Piwi-piRNA complex associates with the piRNA-complementary site in the Drosophila genome and regulates its epigenetic state. Here, we report that Piwi-piRNA complexes bind to numerous piRNA-complementary sequences throughout the genome, implicating piRNAs as a major...

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Identifiers

PMID: 23434410
DOI: 10.1016/j.devcel.2013.01.023
PMCID: PMC3600162

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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