Article

Systematic discovery of directional regulatory motifs associated with human insulator sites

2024-01-23

Abstract excerpt

Insulator proteins function as barriers to enhancer–promoter interactions (EPIs), thereby regulating gene expression. The primary insulator protein in vertebrates is CTCF, a DNA-binding protein (DBP); however, the roles of other DBPs in EPI insulation are not fully understood. To address this, we developed a systematic and comprehensive deep learning–based approach to identify DNA motifs of DBPs associated with in...

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Literature Corpus work: ece5f89a-2d8b-5e0c-926b-92bc648215ae
DOI: 10.1101/2024.01.20.573595

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