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Article

The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells.

Nucleic acids research - 1 Apr 2014

Farr Christine J, Antoniou-Kourounioti Melissa, Mimmack Michael L, Volkov Arsen, Porter Andrew C G

Abstract excerpt

As proliferating cells transit from interphase into M-phase, chromatin undergoes extensive reorganization, and topoisomerase (topo) IIα, the major isoform of this enzyme present in cycling vertebrate cells, plays a key role in this process. In this study, a human cell line conditional null mutant for topo IIα and a derivative expressing an auxin-inducible degron (AID)-tagged version of the protein have been used...

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Identifiers

PMID: 24476913
DOI: 10.1093/nar/gku076
PMCID: PMC3985649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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