Article

Robust CENP-A incorporation in human cells is independent of transcription and cohesin components

2025-05-02

Abstract excerpt

Centromeres are essential chromosomal components that ensure proper cell division by serving as assembly sites for kinetochores, which connect chromosomes to spindle microtubules. Centromeres are marked by the evolutionarily conserved centromere-specific histone H3 variant, CENP-A, which is deposited into centromere nucleosomes during G1 in human cells. Centromeres retain cohesin, a ring-like protein complex durin...

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Literature Corpus work: a0e8a929-da97-524a-8050-674ed05c8057
DOI: 10.1101/2025.04.29.651290

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