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Article

Topoisomerase II mediates meiotic crossover interference.

Nature - 31 Jul 2014

Zhang Liangran, Wang Shunxin, Yin Shen, Hong Soogil, Kim Keun P, Kleckner Nancy

Abstract excerpt

Spatial patterning is a ubiquitous feature of biological systems. Meiotic crossovers provide an interesting example, defined by the classic phenomenon of crossover interference. Here we identify a molecular pathway for interference by analysing crossover patterns in budding yeast. Topoisomerase II plays a central role, thus identifying a new function for this critical molecule. SUMOylation (of topoisomerase II...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25043020
DOI: 10.1038/nature13442
PMCID: PMC4128387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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