Article

The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells

2022-03-21

Abstract excerpt

DNA polymerase epsilon in an essential enzyme, responsible for the synthesis of the leading strand during DNA replication. Deficiencies and mutations in DNA polymerase epsilon catalytic subunit (POLE1) cause severe developmental abnormalities and cancers. Paradoxically, the non-catalytic C-terminal domain of yeast polymerase epsilon catalytic subunit (Pol2) is sufficient for cell survival. The non-catalytic essent...

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Literature Corpus work: 70c6feb3-1f5a-51ac-ad1a-004c9bae1618
DOI: 10.1101/2022.03.21.485102

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