Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line.

Molecular biology of the cell - 1 Dec 2004

Carpenter Adam J, Porter Andrew C G

Abstract excerpt

DNA Topoisomerase IIalpha (topoIIalpha) is a DNA decatenating enzyme, abundant constituent of mammalian mitotic chromosomes, and target of numerous antitumor drugs, but its exact role in chromosome structure and dynamics is unclear. In a powerful new approach to this important problem, with significant advantages over the use of topoII inhibitors or RNA interference, we have generated and characterized a human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Neoplasm
Share to Chromosomes, Human
Share to DNA Topoisomerases, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Doxycycline

Share to Genes, Lethal

Share to Polyploidy

Share to Serine

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 15456904
DOI: 10.1091/mbc.e04-08-0732
PMCID: PMC532048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Construction, characterization, and complementation of a conditional-lethal DNA topoisomerase IIalpha mutant human cell line.PMID 15456904Read ↗

Functional expression of human DNA topoisomerase I and its subcellular localization in HeLa cells.Semantic proximity Read ↗

Nonclassic Functions of Human Topoisomerase I: Genome-Wide and Pharmacologic AnalysesSemantic proximity Read ↗

TDP1 overexpression in human cells counteracts DNA damage mediated by topoisomerases I and II.Semantic proximity Read ↗

The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells.Semantic proximity Read ↗

A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cellsSemantic proximity Read ↗

Human TopBP1 Ensures Genome Integrity during Normal S PhaseSemantic proximity Read ↗

Monitoring the DNA Topoisomerase II Checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

Functional analysis of pathological mutations in DNA topoisomerase 3ASemantic proximity Read ↗

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicitySemantic proximity Read ↗

Selective ploidy ablation, a high-throughput plasmid transfer protocol, identifies new genes affecting topoisomerase I-induced DNA damage.Semantic proximity Read ↗

Analyzing Mitotic Chromosome Structural Defects After Topoisomerase II Inhibition or Mutation.Semantic proximity Read ↗

Type I DNA TopoisomerasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.