Article

Ki-67 is necessary during DNA replication for forks protection and genome stability

2023-04-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The proliferation antigen Ki-67 has been widely used in clinical settings for cancer staging for many years but investigations on its biological functions have lagged. Recently, Ki-67 was shown to regulate both the composition of the chromosome periphery and chromosome behaviour in mitosis as well as to play a role in heterochromatin organisation and gene transcription. Howe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 012cc50c-e815-5fab-8d0b-457036e010ed
DOI: 10.1101/2023.04.18.537310

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ki-67 is necessary during DNA replication for forks protection and genome stabilityDOI 10.1101/2023.04.18.537310Read

Highly diverged non-vertebrate Ki-67 proteins with conserved biophysical and functional propertiesSemantic proximity Read

DDIAS is a single-stranded DNA-binding effector of the TOPBP1-CIP2A complex in mitosisSemantic proximity Read

Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication – transcription conflictsSemantic proximity Read

The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damageSemantic proximity Read

TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cellsSemantic proximity Read

The TRRAP transcription cofactor represses interferon-stimulated genes in colorectal cancer cellsSemantic proximity Read

Ki-67 and the Chromosome Periphery Compartment in Mitosis.Semantic proximity Read

The α isoform of topoisomerase II is required for hypercompaction of mitotic chromosomes in human cells.Semantic proximity Read

The Ki‐67 protein interacts with members of the heterochromatin protein 1 (HP1) family: a potential role in the regulation of higher‐order chromatin structureSemantic proximity Read

Dynamic chromosomal interactions and control of heterochromatin positioning by Ki-67Semantic proximity Read

Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcription controlSemantic proximity Read

Evaluation of the OsTIR1 and AtAFB2 AID systems for chromatin protein degradation in mammalian cellsSemantic proximity Read