Article
Influence of the ABCG2 gout risk 141 K allele on urate metabolism during a fructose challenge.
Arthritis research & therapy - 30 Jan 2014
Dalbeth Nicola, House Meaghan E, Gamble Gregory D, Pool Bregina, Horne Anne, Purvis Lauren, Stewart Angela, Merriman Marilyn, Cadzow Murray, Phipps-Green Amanda, Merriman Tony R
Abstract excerpt
INTRODUCTION: Both genetic variation in ATP-binding cassette sub-family G member 2 (ABCG2) and intake of fructose-containing beverages are major risk factors for hyperuricemia and gout. This study aimed to test the hypothesis that the ABCG2 gout risk allele 141 K promotes the hyperuricaemic respo...
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