The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion.

doi:10.1038/s41467-020-16525-w

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion.

Nature communications - 2 Jun 2020

Hoque Kazi Mirajul, Dixon Eryn E, Lewis Raychel M, Allan Jordyn, Gamble Gregory D, Phipps-Green Amanda J, Halperin Kuhns Victoria L, Horne Anne M, Stamp Lisa K, Merriman Tony R, Dalbeth Nicola, Woodward Owen M

Abstract excerpt

The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and find that participants with the Q141K ABCG2 variant display elevated serum urate, unaltered FEUA, and significant evidence of reduced extra-renal urate excretion. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily G, Member 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Glucose Transport Proteins, Facilitative

Share to Gout

Share to Homeostasis

Share to Hyperuricemia

Share to Intestines

Share to Uric Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 32488095
DOI: 10.1038/s41467-020-16525-w
PMCID: PMC7265540

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion.PMID 32488095Read ↗

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update.Semantic proximity Read ↗

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout.Semantic proximity Read ↗

Functional Characterization of Clinically-Relevant Rare Variants in ABCG2 Identified in a Gout and Hyperuricemia CohortSemantic proximity Read ↗

SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout.Semantic proximity Read ↗

ABCG2 polymorphisms in gout: insights into disease susceptibility and treatment approachesSemantic proximity Read ↗

ABCG2 as a therapeutic target candidate for gout.Semantic proximity Read ↗

Proteomic footprint of serum urate concentration and urate transporter ABCG2 dysfunctional polymorphism: a cross-sectional study.Semantic proximity Read ↗

Hyperuricemia and its related diseases: mechanisms and advances in therapySemantic proximity Read ↗

[Urate transporter and renal hypouricemia].Semantic proximity Read ↗

The Epidemiology and Genetics of Hyperuricemia and Gout across Major Racial Groups: A Literature Review and Population Genetics Secondary Database AnalysisSemantic proximity Read ↗

Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population.Semantic proximity Read ↗

Large-scale whole-exome sequencing association studies identify rare functional variants influencing serum urate levelsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.