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Article

Population-specific influence of SLC2A9 genotype on the acute hyperuricaemic response to a fructose load.

Annals of the rheumatic diseases - 1 Nov 2013

Dalbeth Nicola, House Meaghan E, Gamble Gregory D, Horne Anne, Pool Bregina, Purvis Lauren, Stewart Angela, Merriman Marilyn, Cadzow Murray, Phipps-Green Amanda, Merriman Tony R

Abstract excerpt

BACKGROUND: SLC2A9 is a strong genetic risk factor for hyperuricaemia and gout. SLC2A9 (GLUT9) is a high capacity urate transporter and reportedly transports glucose and fructose. Intake of fructose-containing beverages is associated with development of hyperuricaemia and gout. OBJECTIVE: To determine whether genetic variation in SLC2A9 influences the acute serum urate response to a fructose load. METHODS:...

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Identifiers

PMID: 23349133
DOI: 10.1136/annrheumdis-2012-202732

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