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Article

The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update.

International journal of molecular sciences - 22 Jun 2021

Eckenstaler Robert, Benndorf Ralf A

Abstract excerpt

Urate homeostasis in humans is a complex and highly heritable process that involves i.e., metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate excretion. Importantly, disturbances in urate excretion are a common cause of hyperuricemia and gout. The majority of urate is eliminated by glomerular filtration in the kidney followed by an, as yet, not fully elucidated interplay...

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Source

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Identifiers

PMID: 34206432
DOI: 10.3390/ijms22136678
PMCID: PMC8268734

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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